Parasitic diseases have an enormous health, social and economic impact and are a
particular problem in tropical regions of the world. Diseases caused by protozoa and …

Drug-induced heart and vascular disease remains an important health burden.
Hydroxychloroquine and its predecessor chloroquine are medications commonly used in the …

The 4-aminoquinolines are weak bases that are completely absorbed from the
gastrointestinal tract, sequestered in peripheral tissues, metabolized in the liver to …

The cytokines RANKL and TNF activate NF-κB signaling in osteoclast precursors (OCPs) to
induce osteoclast (OC) formation. Conversely, TNF can limit OC formation through NF-κB …

Hydroxychloroquine (HCQ), a commonly used antimalarial drug in rheumatic diseases, has
shown favorable metabolic effects on both glucose control and lipid profiles. We describe a …

Autoimmune diseases (AD) represent a broad spectrum of chronic conditions that may afflict
specific target organs or multiple systems with a significant burden on quality of life. These …

Lysosomes contribute to a multitude of cellular processes, and the pH of the lysosomal
lumen plays a central mechanistic role in many of these functions. In addition to controlling …

Problem Women with antiphospholipid syndrome (APS) are at risk for pregnancy
complications. Antiphospholipid antibodies (a PL) alter trophoblast function by triggering an …

Objective To evaluate the association of hydroxychloroquine (HCQ) use with lipid profiles in
a Veterans Affairs Rheumatoid Arthritis (VARA) cohort. Methods Lipid profiles in HCQ users …

Background Repositioning of existing drugs has been suggested as a fast track for
developing new anti-malarial agents. The compound libraries of GlaxoSmithKline (GSK) …