Cardiac regeneration is a rapidly evolving and controversial field of research. The
identification some 12 years ago of progenitor cells that reside within the heart spurred …

During development, cardiogenesis is orchestrated by a family of heart progenitors that build
distinct regions of the heart. Each region contains diverse cell types that assemble to form …

The epicardium supports cardiomyocyte proliferation early in development and provides
fibroblasts and vascular smooth muscle cells to the developing heart. The epicardium has …

Adult mammals undergo minimal regeneration following cardiac injury, which severely
compromises cardiac function and contributes to the ongoing burden of heart failure. In …

Aims It is a dogma of cardiovascular pathophysiology that the increased cardiac mass in
response to increased workload is produced by the hypertrophy of the pre-existing …

Heart failure is a growing epidemic caused by cardiomyocyte depletion. Current therapies
prolong survival by protecting remaining cardiomyocytes but are unable to overcome the …

Aims In the adult heart, Notch signalling regulates the response to injury. Notch inhibition
leads to increased cardiomyocyte apoptosis, and exacerbates the development of cardiac …

From historical studies of developing chick hearts to recent advances in regenerative injury
models, the epicardium has arisen as a key player in heart genesis and repair. The …

Resident cardiac stem cells in embryonic, neonatal and adult mammalian heart have been
identified by different membrane markers and transcription factors. However, despite a flurry …

Macrophages are an immune cell type found in every organ of the body. Classically,
macrophages are recognised as housekeeping cells involved in the detection of foreign …