Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major
hallmarks of Alzheimer's disease are extracellular aggregation of amyloid β peptides and …

Oxidative stress caused by reactive species, including reactive oxygen species, reactive
nitrogen species, and unbound, adventitious metal ions (eg, iron [Fe] and copper [Cu]), is an …

Aims Rupture-prone atherosclerotic plaques are characterized by inflammation and a large
necrotic core. Inflammation is linked to high metabolic activity. Advanced glycation …

Methylglyoxal is a reactive dicarbonyl compound produced by glycolytic processing and
identified as a precursor of advanced glycation end products. The elevated methylglyoxal …

Advanced glycation end products (AGEs) and methylglyoxal (MG), an important intermediate
in AGEs synthesis, are thought to contribute to protein aging and to the pathogenesis of age …

Methylglyoxal (MG), one of the uremic toxins, is a highly reactive alpha-dicarbonyl
compound. Recent clinical studies have demonstrated the close associations of cognitive …

Background Enhanced glycolysis leads to elevated levels of the toxic metabolite
methylglyoxal which contributes to loss of protein-function, metabolic imbalance and cell …

MG (methylglyoxal) is an inevitable metabolite derived from glycolysis leading to protein
modification, mitochondrial dysfunction and cell death. The ubiquitous glyoxalase system …

許多疾病﹐ 例如神經退化性疾病﹐ 被認為與低氧/缺氧的傷害以及晚期糖化終產物(advanced
glycation end products, AGEs) 的存在具有相關性﹐ 不過目前AGEs 與缺氧之間的相關性仍少 …

Female fertility peaks at 25 years of age, yet many women put off having children until much
later in life (Nybo Andersen et al. 2000; Hook 1981; Hamilton et al. 2013). Age is a major …