The emerging roles of TCF4 in disease and development
Genome-wide association studies have identified common variants in transcription factor 4
(TCF4) as susceptibility loci for schizophrenia, Fuchs' endothelial corneal dystrophy, and …
(TCF4) as susceptibility loci for schizophrenia, Fuchs' endothelial corneal dystrophy, and …
Animal models of CNS disorders
P McGonigle - Biochemical pharmacology, 2014 - Elsevier
There is intense interest in the development and application of animal models of CNS
disorders to explore pathology and molecular mechanisms, identify potential biomarkers …
disorders to explore pathology and molecular mechanisms, identify potential biomarkers …
Genome-wide association studies: findings at the major histocompatibility complex locus in psychosis
The major histocompatibility complex (MHC) is one of the most intensively investigated,
genetically diverse regions of the genome. In its extended form, it encodes more than 400 …
genetically diverse regions of the genome. In its extended form, it encodes more than 400 …
Th17 pathway–mediated immunopathogenesis of schizophrenia: mechanisms and implications
Schizophrenia is a highly complex and severe neuropsychiatric disorder with an unknown
etiopathology. Evidence for a dysregulated immune system in both the risk for and …
etiopathology. Evidence for a dysregulated immune system in both the risk for and …
Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns
Major nonprimate-primate differences in corticogenesis include the dimensions, precursor
lineages, and developmental timing of the germinal zones (GZs). microRNAs (miRNAs) of …
lineages, and developmental timing of the germinal zones (GZs). microRNAs (miRNAs) of …
Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective
BB Quednow, MM Brzózka, MJ Rossner - Cellular and Molecular Life …, 2014 - Springer
Schizophrenia is a genetically complex disease considered to have a neurodevelopmental
pathogenesis and defined by a broad spectrum of positive and negative symptoms as well …
pathogenesis and defined by a broad spectrum of positive and negative symptoms as well …
Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway
KK Nicodemus, A Hargreaves, D Morris… - JAMA …, 2014 - jamanetwork.com
Importance We investigated the variation in neuropsychological function explained by risk
alleles at the psychosis susceptibility geneZNF804Aand its interacting partners using single …
alleles at the psychosis susceptibility geneZNF804Aand its interacting partners using single …
Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style
BackgroundA single nucleotide polymorphism (rs7914558) within the cyclin M2 (CNNM2)
gene was recently identified as a common risk variant for schizophrenia. The mechanism by …
gene was recently identified as a common risk variant for schizophrenia. The mechanism by …
The immune system and schizophrenia: an update for clinicians
R Upthegrove, NM Barnes - Advances in psychiatric treatment, 2014 - cambridge.org
It has long been recognised that the pathology of schizophrenia may involve the immune
system, yet this has been a relatively neglected area of research. Recent advances in our …
system, yet this has been a relatively neglected area of research. Recent advances in our …
[HTML][HTML] Evolutionary conservation in genes underlying human psychiatric disorders
LM Ogawa, EJ Vallender - Frontiers in human neuroscience, 2014 - frontiersin.org
Many psychiatric diseases observed in humans have tenuous or absent analogs in other
species. Most notable among these are schizophrenia and autism. One hypothesis has …
species. Most notable among these are schizophrenia and autism. One hypothesis has …