Phenotypically identical cells can dramatically vary with respect to behavior during their
lifespan and this variation is reflected in their molecular composition such as the …

Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

Advances in whole-genome and whole-transcriptome amplification have permitted the
sequencing of the minute amounts of DNA and RNA present in a single cell, offering a …

Effective approaches to neuropsychiatric disorders require detailed understanding of the
cellular composition and circuitry of the complex mammalian brain. Here, we present a …

It remains an open question when and how the first cell fate decision is made in mammals.
Using deep single-cell RNA-seq of matched sister blastomeres, we report highly …

During maternal-to-embryonic transition control of embryonic development gradually
switches from maternal RNAs and proteins stored in the oocyte to gene products generated …

DNA methylation at the C-5 position of cytosine (5mC) is one of the best-studied epigenetic
modifications and plays important roles in diverse biological processes. Iterative oxidation of …

We present single-cell clustering using bifurcation analysis (SCUBA), a novel computational
method for extracting lineage relationships from single-cell gene expression data and …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

Following fertilization, gametes undergo epigenetic reprogramming in order to revert to a
totipotent state. How embryonic cells subsequently acquire their fate and the role of …