Investigations of patients with systemic lupus erythematosus have applied insights from
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …

Highlights•Individual ISGs have measurable phenotypes in vivo.•ISGs control viral
pathogenesis through a variety of mechanisms.•ISG effects in vivo are often virus-specific …

Inappropriate or chronic detection of self nucleic acids by the innate immune system
underlies many human autoimmune diseases. We discuss here an unexpected source of …

Proliferating cells are preferentially susceptible to infection by retroviruses. Sterile α motif
and HD domain–containing protein-1 (SAMHD1) is a recently described deoxynucleotide …

As demonstrated in the murine studies of persistent virus infection accompanied by
sustained production of IFN-I, blockade of the IFN-I pathway may reverse the immune …

Human and mouse SAMHD1 proteins block human immunodeficiency virus type 1 (HIV-1)
infection in noncycling human monocytic cells by reducing the intracellular deoxynucleoside …

Background: Sterile α motif and HD domain-containing protein-1 (SAMHD1) inhibits HIV-1
reverse transcription by decreasing the pool of intracellular deoxynucleotides. SAMHD1 is …

SAMHD1 is a GTP-activated nonspecific dNTP triphosphohydrolase that depletes dNTP
pools in resting CD4+ T cells and macrophages and effectively restricts infection by HIV-1 …

Background SAMHD1 degrades deoxyribonucleotides (dNTPs), suppressing viral DNA
synthesis in macrophages. Recently, viral protein X (Vpx) of HIV-2/SIVsm was shown to …

The deoxyribonucleotide triphosphohydrolase SAMHD1 restricts lentiviral infection by
depleting the dNTPs required for viral DNA synthesis. In cultured human fibroblasts …