The changes in diagnostic criteria for major depressive disorder (MDD) from the fourth to the
fifth edition of the D iagnostic and S tatistical M anual of M ental D isorders (DSM) may …

Severe mental illness (SMI) is a broad category that includes schizophrenia, bipolar
disorder, and severe depression. Both genetic disposition and environmental exposures …

Background Major depression is a disabling psychiatric illness with complex origins. Life
stress (childhood adversity and recent stressful events) is a robust risk factor for depression …

BackgroundResearch on gene× environment interaction in major depressive disorder
(MDD) has thus far primarily focused on candidate genes, although genetic effects are …

In the three years since the most recent meta-analysis of the association between the
serotonin transported promoter polymorphism (5-HTTLPR), stress and the development of …

Background Severe mental illness (SMI), including schizophrenia, bipolar disorder and
severe depression, is responsible for a substantial proportion of disability in the population …

A decade of research has demonstrated the explanatory potential of interplay between
genetic variants and environmental factors in the development of common mental disorders …

This review focuses on current research developments in the study of gene by early life
stress (ELS) interactions and depression. ELS refers to aversive experiences during …

Risk for adult psychiatric disorders is partially determined by early-life alterations occurring
during neural circuit formation and maturation. In this perspective, recent data show that the …

Epidemiological studies have shown significant results in the interaction between the
functions of brain-derived neurotrophic factor (BDNF) and 5-HT in mood disorders, such as …