Role of metabolic H2O2 generation: redox signaling and oxidative stress

H Sies - Journal of Biological Chemistry, 2014 - ASBMB
Hydrogen peroxide, the nonradical 2-electron reduction product of oxygen, is a normal
aerobic metabolite occurring at about 10 nm intracellular concentration. In liver, it is …

The role of oxidative stress during inflammatory processes

J Lugrin, N Rosenblatt-Velin, R Parapanov… - Biological …, 2014 - degruyter.com
The production of various reactive oxidant species in excess of endogenous antioxidant
defense mechanisms promotes the development of a state of oxidative stress, with …

Towards identifying novel anti-Eimeria agents: trace elements, vitamins, and plant-based natural products

F Wunderlich, S Al-Quraishy, H Steinbrenner… - Parasitology …, 2014 - Springer
Eimeriosis, a widespread infectious disease of livestock, is caused by coccidian protozoans
of the genus Eimeria. These obligate intracellular parasites strike the digestive tract of their …

[HTML][HTML] Classification of oxidative stress based on its intensity

VI Lushchak - EXCLI journal, 2014 - ncbi.nlm.nih.gov
In living organisms production of reactive oxygen species (ROS) is counterbalanced by their
elimination and/or prevention of formation which in concert can typically maintain a steady …

[PDF][PDF] Redox proteomics: from protein modifications to cellular dysfunction and disease

DA Butterfield, I Dalle‐Donne - Mass spectrometry reviews, 2014 - wrd.as.uky.edu
Reactive oxygen and nitrogen species (ROS and RNS, respectively) are part of any aerobic
lifestyle/metabolism: low (ie, subtoxic) concentrations of selected ROS and RNS are …

[HTML][HTML] Organochalcogen compounds from glycerol: Synthesis of new antioxidants

PC Nobre, EL Borges, CM Silva, AM Casaril… - Bioorganic & Medicinal …, 2014 - Elsevier
We describe here a simple method for the synthesis of glycerol derivatives containing an
organochalcogen unit (Se, Te and S) using NaBH 4 and PEG-400 as a solvent. The new …

Oxidative balance score and risk for incident prostate cancer in a prospective US cohort study

S Lakkur, M Goodman, RM Bostick, J Citronberg… - Annals of …, 2014 - Elsevier
Purpose Oxidative stress is defined as an imbalance between pro-oxidants and
antioxidants. Previous research found that a single comprehensive oxidative balance score …

Oxidative balance score and oxidative stress biomarkers in a study of Whites, African Americans, and African immigrants

S Lakkur, RM Bostick, D Roblin, M Ndirangu… - Biomarkers, 2014 - Taylor & Francis
Context: Oxidative balance score (OBS) is a composite measure of multiple pro-and
antioxidant exposures. Objective: To investigate associations of OBS with F2-isoprostanes …

Phase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphoma

PM Barr, TP Miller, JW Friedberg… - Blood, The Journal …, 2014 - ashpublications.org
Lymphoma cells are subject to higher levels of oxidative stress compared with their normal
counterparts and may be vulnerable to manipulations of the cellular redox balance. We …

Redox pioneer: professor helmut sies

DP Jones, R Radi - Antioxidants & redox signaling, 2014 - liebertpub.com
Abstract Professor Helmut Sies Dr. Helmut Sies (MD, 1967) is recognized as a Redox
Pioneer, because he authored five articles on oxidative stress, lycopene, and glutathione …