[HTML][HTML] Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development …

KE Caudle, TE Klein, JM Hoffman, DJ Müller… - Current drug …, 2014 - ncbi.nlm.nih.gov
Abstract The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes
genotype-based drug guidelines to help clinicians understand how available genetic test …

The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin‐Induced Myopathy: 2014 Update

LB Ramsey, SG Johnson, KE Caudle… - Clinical …, 2014 - Wiley Online Library
Simvastatin is among the most commonly used prescription medications for cholesterol
reduction. A single coding single‐nucleotide polymorphism, rs4149056T> C, in SLCO1B1 …

[HTML][HTML] Secondary use of clinical data: the Vanderbilt approach

I Danciu, JD Cowan, M Basford, X Wang, A Saip… - Journal of biomedical …, 2014 - Elsevier
The last decade has seen an exponential growth in the quantity of clinical data collected
nationwide, triggering an increase in opportunities to reuse the data for biomedical research …

Development and use of active clinical decision support for preemptive pharmacogenomics

GC Bell, KR Crews, MR Wilkinson… - Journal of the …, 2014 - academic.oup.com
Background Active clinical decision support (CDS) delivered through an electronic health
record (EHR) facilitates gene-based drug prescribing and other applications of genomics to …

Using natural language processing to improve efficiency of manual chart abstraction in research: the case of breast cancer recurrence

DS Carrell, S Halgrim, DT Tran… - American journal of …, 2014 - academic.oup.com
The increasing availability of electronic health records (EHRs) creates opportunities for
automated extraction of information from clinical text. We hypothesized that natural language …

Pharmacogenomics in oncology care

KK Filipski, LE Mechanic, R Long… - Frontiers in genetics, 2014 - frontiersin.org
Cancer pharmacogenomics have contributed a number of important discoveries to current
cancer treatment, changing the paradigm of treatment decisions. Both somatic and germline …

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA‐B Genotype and Abacavir Dosing: 2014 Update

MA Martin, JM Hoffman, RR Freimuth… - Clinical …, 2014 - Wiley Online Library
The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for HLA‐B
Genotype and Abacavir Dosing were originally published in April 2012. We reviewed recent …

Usability evaluation of pharmacogenomics clinical decision support aids and clinical knowledge resources in a computerized provider order entry system: a mixed …

EB Devine, CJ Lee, CL Overby, N Abernethy… - International journal of …, 2014 - Elsevier
Abstract Background Pharmacogenomics (PGx) is positioned to have a widespread impact
on the practice of medicine, yet physician acceptance is low. The presentation of context …

Implementation of personalized medicine services in community pharmacies: perceptions of independent community pharmacists

KM Alexander, HS Divine, CR Hanna, Y Gokun… - Journal of the American …, 2014 - Elsevier
Objectives To evaluate the perceptions of independent community pharmacists within a
regional independent community pharmacy cooperative on implementing personalized …

Improving the power of genetic association tests with imperfect phenotype derived from electronic medical records

JA Sinnott, W Dai, KP Liao, SY Shaw… - Human genetics, 2014 - Springer
To reduce costs and improve clinical relevance of genetic studies, there has been
increasing interest in performing such studies in hospital-based cohorts by linking …