Objective: During the past decades, increasing efforts have been invested in studies to
unravel the influence of genetic factors on antipsychotic (AP) dosage, treatment response …

This review considers pharmacogenetics of the so called 'second-generation'antipsychotics.
Findings for polymorphisms replicating in more than one study are emphasized and …

Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and
mortality and, whilst smoking remains the single most important risk factor, COPD risk is …

Wild populations of northern bobwhites (Colinus virginianus; hereafter bobwhite) have
declined across nearly all of their US range, and despite their importance as an …

Cognitive performance is an important component of healthy aging. Type 2 diabetes (T2D) is
associated with negative outcomes for the brain and cognition, although causal mechanisms …

Glucagon-like peptide 1 receptor (GLP1R) signaling has been shown to have antipsychotic
properties in animal models and to impact glucose-dependent insulin release, satiety …

The ability to reason with language is a highly valued cognitive capacity that correlates with
IQ measures and is sensitive to damage in language areas. The Penn Verbal Reasoning …

Objective Identify genetic factors associated with cognitive maintenance in late life and
assess their association with gray matter (GM) volume in brain networks affected in aging …

The most common neurological disorders, including neurodegenerative diseases and
psychiatric disorders, have received recent attention with regards to pharmacogenomics and …

精神分裂症(schizophrenia) 给家庭及社会带来沉重负担, 药物治疗是目前最主要的治疗方法.
第1 代抗精神病药主要改善精神分裂症患者的阳性症状, 但由于其对多巴胺受体亲和力高 …