Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor
(NR) superfamily of ligand-dependent transcription factors (TFs) and function as a master …

Leptin is hypothesized to function as a negative feedback signal in the regulation of energy
balance. It is produced primarily by adipose tissue and circulating concentrations correlate …

The connection between an altered gut microbiota and metabolic disorders such as obesity,
diabetes, and cardiovascular disease is well established,. Defects in preserving the integrity …

Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid
chaperone expressed primarily in adipocytes and myeloid cells and implicated in the …

Peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein
α (C/EBPα) are key activators of adipogenesis. They mutually induce the expression of each …

The nuclear receptor PPARγ is a master regulator of adipogenesis. PPARγ is highly
expressed in adipose tissues and its expression is markedly induced during adipogenesis …

Adipose tissues have striking plasticity, highlighted by childhood and adult obesity. Using
adipose lineage analyses, smooth muscle actin (SMA)-mural cell-fate mapping, and …

The family of inhibitor of differentiation (Id) proteins is a group of evolutionarily conserved
molecules, which play important regulatory roles in organisms ranging from Drosophila to …

Osteoporosis is a common chronic condition associated with progressive loss of bone
mineral density (BMD) and compromised bone strength, with increasing risk of fracture over …

Thyroid carcinoma is the most common endocrine malignancy, and its incidence is
continuing to increase. Most thyroid carcinomas contain one of several known driver …