Autoimmune diseases are a range of diseases in which the immune response to self-
antigens results in damage or dysfunction of tissues. Autoimmune diseases can be systemic …

Gene clusters are common features of prokaryotic genomes also present in eukaryotes.
Most clustered genes known are involved in the biosynthesis of secondary metabolites …

Genotyping of classical human leukocyte antigen (HLA) alleles is an essential tool in the
analysis of diseases and adverse drug reactions with associations mapping to the major …

The 1000 Genomes Project aims to provide a deep characterization of human genome
sequence variation by sequencing at a level that should allow the genome-wide detection of …

The major histocompatibility complex (MHC) is one of the most intensively investigated,
genetically diverse regions of the genome. In its extended form, it encodes more than 400 …

Autoimmune type 1 diabetes is characterized by selective destruction of insulin-secreting
beta cells in the pancreas of genetically susceptible individuals. The mechanisms …

Type 1 diabetes (T1D) is an autoimmune disease with a prolonged and variable latent
period that culminates in the destruction of pancreatic β-cells and the development of …

Atopic dermatitis is a common inflammatory disease caused by a combination of genetic and
environmental factors. Genome‐wide association study (GWAS) is a comprehensive and …

Genetic association of the major histocompatibility complex (MHC) locus is well established
in systemic lupus erythematosus (SLE), but the causal functional variants in this region have …

Working memory, the capacity of actively maintaining task-relevant information during a
cognitive task, is a heritable trait. Working memory deficits are characteristic for many …