Glucagon-like peptide-1: glucose homeostasis and beyond

YM Cho, Y Fujita, TJ Kieffer - Annual review of physiology, 2014 - annualreviews.org
Glucagon-like peptide-1 (GLP-1), an incretin hormone secreted primarily from the intestinal
L-cells in response to meals, modulates nutrient homeostasis via actions exerted in multiple …

Glucagon and type 2 diabetes: the return of the alpha cell

A Lund, JI Bagger, M Christensen, FK Knop… - Current diabetes …, 2014 - Springer
In normal physiology, glucagon from pancreatic alpha cells plays an important role in
maintaining glucose homeostasis via its regulatory effect on hepatic glucose production …

The impact of nanoparticles on the mucosal translocation and transport of GLP-1 across the intestinal epithelium

F Araújo, N Shrestha, MA Shahbazi, P Fonte… - Biomaterials, 2014 - Elsevier
Abstract Glucagon like peptide-1 (GLP-1) is an incretin hormone that is in the pipeline for
type 2 diabetes mellitus (T2DM) therapy. However, oral administration of GLP-1 is hindered …

Incretins: their physiology and application in the treatment of diabetes mellitus

HM Tasyurek, HA Altunbas, MK Balci… - … research and reviews, 2014 - Wiley Online Library
Therapies targeting the action of incretin hormones have been under close scrutiny in recent
years. The incretin effect has been defined as postprandial enhancement of insulin secretion …

[HTML][HTML] Beneficial effects of once-daily lixisenatide on overall and postprandial glycemic levels without significant excess of hypoglycemia in type 2 diabetes …

J Rosenstock, M Hanefeld, P Shamanna… - Journal of Diabetes and …, 2014 - Elsevier
Aims To assess efficacy and safety of lixisenatide once-daily versus placebo in Type 2
diabetes mellitus (T2DM) patients inadequately controlled on sulfonylurea (SU)±metformin …

Glucagon-like peptide-1 as a key regulator of lipid and lipoprotein metabolism in fasting and postprandial states

S Farr, J Taher, K Adeli - Cardiovascular & Haematological …, 2014 - ingentaconnect.com
Insulin resistance and the metabolic syndrome are associated with fasting and postprandial
dyslipidemia. This involves the hepatic and intestinal overproduction of very low density …

Dietary sweet potato (Ipomoea batatas L.) leaf extract attenuates hyperglycaemia by enhancing the secretion of glucagon-like peptide-1 (GLP-1)

R Nagamine, S Ueno, M Tsubata, K Yamaguchi… - Food & Function, 2014 - pubs.rsc.org
'Suioh', a sweet potato (Ipomoea batatas L.) cultivar developed in Japan, has edible leaves
and stems. The sweet potato leaves contain polyphenols such as caffeoylquinic acid (CQA) …

Nutrient regulation of glucagon secretion: involvement in metabolism and diabetes

L Marroqui, P Alonso-Magdalena, B Merino… - Nutrition research …, 2014 - cambridge.org
Glucose homeostasis is precisely regulated by glucagon and insulin, which are released by
pancreatic α-and β-cells, respectively. While β-cells have been the focus of intense …

[HTML][HTML] Complicaciones de la diabetes y su asociación con el estrés oxidativo: un viaje hacia el daño endotelial

MA Storino, MA Contreras, J Rojano, R Serrano… - Revista colombiana de …, 2014 - Elsevier
La diabetes es un trastorno metabólico que se ha incrementado en Latinoamérica y
Venezuela en la última década. Ejerce una influencia considerable en la morbimortalidad …

Therapies for inter-relating diabetes and obesity–GLP-1 and obesity

EW Iepsen, SS Torekov, JJ Holst - Expert opinion on …, 2014 - Taylor & Francis
Introduction: The dramatic rise in the prevalence of obesity and type 2 diabetes mellitus
(T2DM) is associated with increased mortality, morbidity as well as public health care …