Neurological disorders are prevalent worldwide. Cerebrovascular diseases (CVDs), which
account for 55% of all neurological diseases, are the leading cause of permanent disability …

Cerebral amyloid angiopathy (CAA), the accumulation of β-amyloid (Aβ) peptides in the
walls of cerebral blood vessels, is observed in the majority of Alzheimer's disease (AD) …

In Alzheimer's disease, amyloid‐β (Aβ) accumulates as insoluble plaques in the brain and
deposits in blood vessel walls as cerebral amyloid angiopathy (CAA). The severity of CAA …

The blood-brain barrier protects brain tissue from potentially harmful plasma components.
Small vessel disease (SVD; also termed arteriolosclerosis) is common in the brains of older …

Barrier characteristics of brain endothelial cells forming the blood–brain barrier (BBB) are
tightly regulated by cellular and acellular components of the neurovascular unit. During …

Currently, there is great interest in the assembly and function of cerebral endothelial, glial
and neuronal cells that form the anatomical basis of the neurovascular unit (NVU) to …

Neural extracellular matrix (ECM) is different from the normal ECM in other organs in that it
has low fibrous protein content and high carbohydrate content. One of the key carbohydrate …

The capillary basement membranes are examined in severe traumatic brain injuries,
vascular malformation, congenital hydrocephalus and brain tumours. They exhibit …

Abstract Prothrombin kringle-2 (pKr-2), a domain of prothrombin, can cause the
degeneration of mesencephalic dopaminergic neurons through microglial activation …

Proper function of the neurovasculature is required for optimal brain function and preventing
neuroinflammation and neurodegeneration. During a large number of neurological …