Delivery of inhalation drugs to children for asthma and other respiratory diseases
Infants and children constitute a patient group that has unique requirements in pulmonary
drug delivery. Since their lungs develop continuously until they reach adulthood, the airways …
drug delivery. Since their lungs develop continuously until they reach adulthood, the airways …
Pediatric In Vitro and In Silico Models of Deposition via Oral and Nasal Inhalation
Respiratory tract deposition models provide a useful method for optimizing the design and
administration of inhaled pharmaceutical aerosols, and can be useful for estimating …
administration of inhaled pharmaceutical aerosols, and can be useful for estimating …
Growth of nasal and laryngeal airways in children: implications in breathing and inhaled aerosol dynamics
BACKGROUND: The human respiratory airway undergoes dramatic growth during infancy
and childhood, which induces substantial variability in air flow pattern and particle …
and childhood, which induces substantial variability in air flow pattern and particle …
Comparison of In Vitro Deposition of Pharmaceutical Aerosols in an Idealized Child Throat with In Vivo Deposition in the Upper Respiratory Tract of Children
Purpose Deposition of drug emitted from two commercially available inhalers was measured
in an in vitro child oral airway model and compared to existing in vivo data to examine the …
in an in vitro child oral airway model and compared to existing in vivo data to examine the …
Nasal deposition in infants and children
Background: The variability of particle deposition in infant and child nasal airways is
significant due to the airway geometry and breathing rate. Estimation of particle deposition in …
significant due to the airway geometry and breathing rate. Estimation of particle deposition in …
Targeted lung delivery of nasally administered aerosols
Using the nasal route to deliver pharmaceutical aerosols to the lungs has a number of
advantages, including coadministration during noninvasive ventilation. The objective of this …
advantages, including coadministration during noninvasive ventilation. The objective of this …
Variability in nose-to-lung aerosol delivery
Nasal delivery of lung targeted pharmaceutical aerosols is ideal for drugs that need to be
administered during high flow nasal cannula (HFNC) gas delivery, but based on previous …
administered during high flow nasal cannula (HFNC) gas delivery, but based on previous …
Measurements of total aerosol deposition in intrathoracic conducting airway replicas of children
The objective of this research was to obtain a correlation that quantitatively predicts
micrometer-sized aerosol particle deposition in the upper conducting airways (trachea to …
micrometer-sized aerosol particle deposition in the upper conducting airways (trachea to …
Absence of detectable influenza RNA transmitted via aerosol during various human respiratory activities–experiments from Singapore and Hong Kong
Two independent studies by two separate research teams (from Hong Kong and Singapore)
failed to detect any influenza RNA landing on, or inhaled by, a life-like, human manikin …
failed to detect any influenza RNA landing on, or inhaled by, a life-like, human manikin …
Effects of the facial interface on inhalation and deposition of micrometer particles in calm air in a child airway model
Context: How the facial interface affects particle inhalability and depositions within the
airway is not well understood. Previous studies of inhalation dosimetry are limited to either …
airway is not well understood. Previous studies of inhalation dosimetry are limited to either …