Vaccines are one of the most effective interventions to improve public health, however, the
generation of highly effective vaccines for many diseases has remained difficult. Three …

A highly efficacious pre-erythrocytic stage vaccine would be an important tool for the control
and elimination of malaria but is currently unavailable. High-level protection in humans can …

Although recent control measures have significantly reduced malaria cases and deaths in
many endemic areas, an effective vaccine will be essential to eradicate this parasitic …

Malaria plagues one out of every 30 humans and contributes to almost a million deaths, and
the problem could worsen. Our current therapeutic options are compromised by emerging …

Conclusion Clearly, disease prevention by vaccination is recognized by all as a superior
strategy to manage diseases. There is an urgent need to emphasize this approach by …

Malaria is a major public health problem, with an estimated 207 million cases and 627,000
deaths each year as well as associated socio-economic costs. Considerable inroads have …

Malaria is a major cause of mortality and morbidity and an effective vaccine is an urgent
global health priority. This thesis evaluates the liver stage viral vector regimen ChAd63 …