Highlights•Elderly people commonly show signs of low level systemic inflammation.•Causes
include presence of senescent cells, chronic infections and obesity.•Systemic inflammation …

Abstract p16INK4a, located on chromosome 9p21. 3, is lost among a cluster of neighboring
tumor suppressor genes. Although it is classically known for its capacity to inhibit cyclin …

Written by experienced and internationally renowned contributors, this is the fourth edition of
what has become the standard reference for cosmetic scientists and dermatologists seeking …

Cell senescence is one of the major paradigms of aging research. It started with the
demonstration by L. Hayflick of the limited number of divisions by normal, nontransformed …

Ageing is influenced by the intrinsic disposition delineating what is maximally possible and
extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic …

1. Averbuch D, Orasch C, Cordonnier C, Livermore DM, Mikulska M, Viscoli C, et al.
European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the …

Mammalian aging is complex and incompletely understood. Although significant effort has
been spent addressing the genetics or, more recently, the pharmacology of aging, the …

Senescence is a state wherein cells are metabolically active but are unable to replicate due
to the increased expression of cell cycle check point proteins, such as p16INK4A, that …

Представлена методология количественной оценки интегрального уровня здоровья и
старения на основании системного показателя «биологический возраст»(БВ) …

The myth of the Minotaur 1 is more than 4000 years old. Yet it offers a cogent metaphor of
the complexity of modern cancer treatment. Like cancer, the Minotaur with the head of the …