[HTML][HTML] Addressing the global burden of chronic kidney disease through clinical and translational research
A Ojo - Transactions of the American Clinical and …, 2014 - ncbi.nlm.nih.gov
Worldwide, an estimated 200 million people have chronic kidney disease (CKD). In the
United States, African Americans (AAs) have a four-fold excess risk of CKD compared to non …
United States, African Americans (AAs) have a four-fold excess risk of CKD compared to non …
APOL1 kidney risk alleles: population genetics and disease associations
APOL1 kidney disease is a unique case in the field of the genetics of common disease: 2
variants (termed G1 and G2) with high population frequency have been repeatedly …
variants (termed G1 and G2) with high population frequency have been repeatedly …
Evolution of the primate trypanolytic factor APOL1
R Thomson, G Genovese, C Canon… - Proceedings of the …, 2014 - National Acad Sciences
ApolipoproteinL1 (APOL1) protects humans and some primates against several African
trypanosomes. APOL1 genetic variants strongly associated with kidney disease in African …
trypanosomes. APOL1 genetic variants strongly associated with kidney disease in African …
The molecular arms race between African trypanosomes and humans
E Pays, B Vanhollebeke, P Uzureau… - Nature Reviews …, 2014 - nature.com
Humans can survive bloodstream infection by African trypanosomes, owing to the activity of
serum complexes that have efficient trypanosome-killing ability. The two trypanosome …
serum complexes that have efficient trypanosome-killing ability. The two trypanosome …
[HTML][HTML] African Americans, hypertension and the renin angiotensin system
SF Williams, SB Nicholas, ND Vaziri… - World journal of …, 2014 - ncbi.nlm.nih.gov
African Americans have exceptionally high rates of hypertension and hypertension related
complications. It is commonly reported that the blood pressure lowering efficacy of renin …
complications. It is commonly reported that the blood pressure lowering efficacy of renin …
[HTML][HTML] Host genetics and parasitic infections
VD Mangano, D Modiano - Clinical Microbiology and Infection, 2014 - Elsevier
Parasites still impose a high death and disability burden on human populations, and are
therefore likely to act as selective factors for genetic adaptations. Genetic epidemiological …
therefore likely to act as selective factors for genetic adaptations. Genetic epidemiological …
Gene–gene interactions in APOL1-associated nephropathy
Background Two APOL1 nephropathy variants confer substantial risk for non-diabetic end-
stage kidney disease (ESKD) in African Americans (AAs). Since not all genetically high-risk …
stage kidney disease (ESKD) in African Americans (AAs). Since not all genetically high-risk …
[HTML][HTML] Haptoglobin (HP) and Haptoglobin-related protein (HPR) copy number variation, natural selection, and trypanosomiasis
Haptoglobin, coded by the HP gene, is a plasma protein that acts as a scavenger for free
heme, and haptoglobin-related protein (coded by the HPR gene) forms part of the …
heme, and haptoglobin-related protein (coded by the HPR gene) forms part of the …
Predictors of HIV-associated nephropathy
S Waheed, MG Atta - Expert review of anti-infective therapy, 2014 - Taylor & Francis
Renal disease accounts for significant morbidity and mortality in patients with HIV-1
infection. HIV-associated nephropathy (HIVAN) is an important cause of end stage renal …
infection. HIV-associated nephropathy (HIVAN) is an important cause of end stage renal …
The biology of APOL1 with insights into the association between APOL1 variants and chronic kidney disease
SM Madhavan, JF O'Toole - Clinical and experimental nephrology, 2014 - Springer
Recent studies have identified genetic variants in APOL1 that may contribute to the
increased incidence of kidney disease in populations with African ancestry. Here, we review …
increased incidence of kidney disease in populations with African ancestry. Here, we review …