It is well accepted that expression of mutant p53 involves the gain of oncogenic-specific
activities accentuating the malignant phenotype. Depending on the specific cancer type …

Pancreatic cancer is one of the most aggressive and lethal malignancies. Despite
remarkable progress in understanding pancreatic carcinogenesis at the molecular level, as …

To achieve deep tumor penetration of large‐sized nanoparticles (NPs), we have developed
a reversible swelling–shrinking nanogel in response to pH variation for a sequential intra …

Cancer stem cells (CSCs) are thought to drive tumor growth, metastasis and
chemoresistance. Although surface markers such as CD133 and CD44 have been …

Head and neck squamous cell carcinomas (HNSCC) contain a small subpopulation of stem
cells endowed with unique capacity to generate tumors. These cancer stem cells (CSC) are …

Background Pancreatic cancer is one of the most aggressive cancers, and the
aggressiveness of pancreatic cancer is in part due to its intrinsic and extrinsic drug …

According to the cancer stem cell (CSC) hypothesis, the aggressive growth and early
metastasis of pancreatic ductal adenocarcinoma (PDA) is due to the activity of CSCs, which …

Subpopulations of cancer stem cells (CSCs) or cancer stem-like cells (CSLCs) have been
identified from most tumors, including pancreatic cancer (PC), and the existence of these …

Background: Angiogenesis is essential for tumour growth and metastasis. There are
conflicting reports as to whether microvessel density (MVD) using the endothelial marker …

Pancreatic cancer is a devastating disease with an overall 5-year survival rate less than 5%.
Multiple signaling pathways are implicated in the pathogenesis of pancreatic cancer, such …