Tuberculosis continues to kill 1· 4 million people annually. During the past 5 years, an
alarming increase in the number of patients with multidrug-resistant tuberculosis and …

Without better vaccines it is unlikely that tuberculosis (TB) will ever be eliminated. An
investment of∼€ 560 million is considered necessary to develop a new, effective vaccine in …

Rationale: In the absence of active tuberculosis, a positive tuberculin skin test (TST) or
interferon-γ release assay (IGRA) result defines latent infection with Mycobacterium …

Latent infection with Mycobacterium tuberculosis (LTBI) is defined by the presence of M.
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …

Background Preventing active tuberculosis (TB) from developing in people with latent
tuberculosis infection (LTBI) is important for global TB control. Isoniazid (INH) for six to nine …

An association between biologic agents and reactivation of active disease from latent
tuberculosis infection (LTBI) has been established. Screening for LTBI is, therefore, now …

Background The QuantiFERON-TB-Gold Test (QFT) is more specific than the Mantoux skin-
test to discriminate between Mycobacterium tuberculosis (MTB) and non-tuberculous …

Background The BCG vaccine's ability to prevent Mycobacterium tuberculosis infection (MTI)
remains highly debated. In Greenland, BCG vaccination was introduced in 1955, but was …

Objective Performance of IFN-γ assays in children is compromised. Therefore, we
investigated the utility of IP-10 for the detection of active tuberculosis (TB) and latent …

Interferon-gamma release assays (IGRAs) represent the first new tool to diagnose latent
tuberculosis infection for more than 100 years. They have advantages over the traditional …