Cell differentiation is an essential process for the development, growth, reproduction, and
longevity of all multicellular organisms, and its regulation has been the focus of intense …

Since the discovery of LGR5 as a marker of intestinal stem cells, the field has developed
explosively and led to many new avenues of research. The inner workings of the intestinal …

Engineered endonucleases, such as zinc-finger nucleases (ZFNs), transcription activator-
like effector nucleases (TALENs) and the clustered regularly interspaced short palindromic …

CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into
macrophages at high efficiencies and enhances reprogramming into induced pluripotent …

Conventional embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) derived
from primates resemble mouse epiblast stem cells, raising an intriguing question regarding …

Generation of induced pluripotent stem cells (iPSCs) via the ectopic expression of
reprogramming factors is a simple, advanced, yet often perplexing technology due to low …

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic tumor, is a
highly aggressive human cancer with the lowest five-year survival rate of any human …

The inner cell mass (ICM) and trophoblast cell lineages duet early embryonic development
in mammals. After implantation, the ICM forms the embryo proper as well as some …

The creation of induced pluripotent stem cells (iPSCs) from somatic cells by ectopic
expression of transcription factors has galvanized the fields of regenerative medicine and …

Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) shares much
similarity to the cancer initiation process, and the molecular mechanisms underlying both …