Abstract Dipeptidyl peptidase-4 (DPP4) is a widely expressed enzyme transducing actions
through an anchored transmembrane molecule and a soluble circulating protein. Both …

Alzheimer disease (AD) is the most common form of dementia among the elderly and is
characterized by progressive loss of memory and cognition. Epidemiological data show that …

For over 100 years it was believed that dietary protein must be completely hydrolysed before
its constituent amino acids could be absorbed via specific amino acid transport systems. It is …

Abstract Insulin and Insulin Growth Factor-1 (IGF-1) play a major role in body homeostasis
and glucose regulation. They also have paracrine/autocrine functions in the brain. The …

Summary Glucagon-like peptide-1 (GLP-1), an insulinotropic gut peptide released after
eating, is essential for normal glucose tolerance (GT). To determine whether this effect is …

Therapies targeting the action of incretin hormones have been under close scrutiny in recent
years. The incretin effect has been defined as postprandial enhancement of insulin secretion …

Dipeptidyl peptidase-4 (DPP-4) inhibitors prevent degradation of incretin hormones
(glucagon-like peptide 1 [GLP-1] and glucose-dependent insulinotropic polypeptide [GIP]) …

Using the hyperglycemic and euglycemic clamp, we demonstrated impaired β-cell function
in obese youth with increasing dysglycemia. Herein we describe oral glucose tolerance test …

Aims/hypothesis Inhibition of the enzyme dipeptidyl peptidase 4 (DPP-4), which cleaves and
inactivates glucagon-like peptide 1 (GLP-1), is a glucose-lowering strategy in type 2 …

Insulin resistance and the metabolic syndrome are associated with fasting and postprandial
dyslipidemia. This involves the hepatic and intestinal overproduction of very low density …