Defining functional DNA elements in the human genome
With the completion of the human genome sequence, attention turned to identifying and
annotating its functional DNA elements. As a complement to genetic and comparative …
annotating its functional DNA elements. As a complement to genetic and comparative …
Common features of microRNA target prediction tools
SM Peterson, JA Thompson, ML Ufkin… - Frontiers in …, 2014 - frontiersin.org
The human genome encodes for over 1800 microRNAs (miRNAs), which are short non-
coding RNA molecules that function to regulate gene expression post-transcriptionally. Due …
coding RNA molecules that function to regulate gene expression post-transcriptionally. Due …
A general framework for estimating the relative pathogenicity of human genetic variants
Current methods for annotating and interpreting human genetic variation tend to exploit a
single information type (for example, conservation) and/or are restricted in scope (for …
single information type (for example, conservation) and/or are restricted in scope (for …
The genomic substrate for adaptive radiation in African cichlid fish
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great
Lakes of East Africa. To understand the molecular mechanisms underlying cichlid …
Lakes of East Africa. To understand the molecular mechanisms underlying cichlid …
The evolution of lncRNA repertoires and expression patterns in tetrapods
Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The
evolutionary history of lncRNAs can provide insights into their functionality, but the absence …
evolutionary history of lncRNAs can provide insights into their functionality, but the absence …
Obesity-associated variants within FTO form long-range functional connections with IRX3
S Smemo, JJ Tena, KH Kim, ER Gamazon, NJ Sakabe… - Nature, 2014 - nature.com
Genome-wide association studies (GWAS) have reproducibly associated variants within
introns of FTO with increased risk for obesity and type 2 diabetes (T2D),,. Although the …
introns of FTO with increased risk for obesity and type 2 diabetes (T2D),,. Although the …
Comparative genomics reveals insights into avian genome evolution and adaptation
Birds are the most species-rich class of tetrapod vertebrates and have wide relevance
across many research fields. We explored bird macroevolution using full genomes from 48 …
across many research fields. We explored bird macroevolution using full genomes from 48 …
[HTML][HTML] Genome sequencing highlights the dynamic early history of dogs
To identify genetic changes underlying dog domestication and reconstruct their early
evolutionary history, we generated high-quality genome sequences from three gray wolves …
evolutionary history, we generated high-quality genome sequences from three gray wolves …
RBPmap: a web server for mapping binding sites of RNA-binding proteins
Regulation of gene expression is executed in many cases by RNA-binding proteins (RBPs)
that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via …
that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via …
A highly conserved program of neuronal microexons is misregulated in autistic brains
Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However,
which of the myriad of detected AS events provide important biological functions is not well …
which of the myriad of detected AS events provide important biological functions is not well …