Reverse engineering and identification in systems biology: strategies, perspectives and challenges
AF Villaverde, JR Banga - Journal of the Royal Society …, 2014 - royalsocietypublishing.org
The interplay of mathematical modelling with experiments is one of the central elements in
systems biology. The aim of reverse engineering is to infer, analyse and understand …
systems biology. The aim of reverse engineering is to infer, analyse and understand …
Optimal experiment design for model selection in biochemical networks
Background Mathematical modeling is often used to formalize hypotheses on how a
biochemical network operates by discriminating between competing models. Bayesian …
biochemical network operates by discriminating between competing models. Bayesian …
Experimental design schemes for learning Boolean network models
Motivation: A holy grail of biological research is a working model of the cell. Current
modeling frameworks, especially in the protein–protein interaction domain, are mostly …
modeling frameworks, especially in the protein–protein interaction domain, are mostly …
Combining test statistics and models in bootstrapped model rejection: it is a balancing act
R Johansson, P Strålfors, G Cedersund - BMC systems biology, 2014 - Springer
Background Model rejections lie at the heart of systems biology, since they provide
conclusive statements: that the corresponding mechanistic assumptions do not serve as …
conclusive statements: that the corresponding mechanistic assumptions do not serve as …
[PDF][PDF] Statistical model identification: dynamical processes and large-scale networks in systems biology
R Flassig - 2014 - pure.mpg.de
The use of mathematical models for analyzing complex biological processes, including
metabolism, signal transduction and gene regulation in mammalian cells or bacteria, is a …
metabolism, signal transduction and gene regulation in mammalian cells or bacteria, is a …
Reasoning on the response of logical signaling networks with answer set programming
S Videla - 2014 - theses.hal.science
Deciphering the functioning of biological networks is one of the central tasks in systems
biology. In particular, signal transduction networks are crucial for the understanding of the …
biology. In particular, signal transduction networks are crucial for the understanding of the …
LMI based loop shaping control of biological circuits
Over the past few decades there has been a lot of work in the field of synthetic biology, in
order to understand the underlying concepts and cast them as a problem in chemistry …
order to understand the underlying concepts and cast them as a problem in chemistry …
[HTML][HTML] Combining test statistics and models in bootstrapped model rejection: it is a balancing act
G Cedersund, P Strålfors, R Johansson - 2014 - oa.las.ac.cn
Background Model rejections lie at the heart of systems biology, since they provide
conclusive statements: that the corresponding mechanistic assumptions do not serve as …
conclusive statements: that the corresponding mechanistic assumptions do not serve as …
[引用][C] Reasoning on the response of logical signaling networks with Answer Set Programming
M DUCASSE - 2014 - Université Paris Sud