Convection‐enhanced drug delivery to the brain: Therapeutic potential and neuropathological considerations

NU Barua, SS Gill, S Love - Brain pathology, 2014 - Wiley Online Library
Convection‐enhanced delivery (CED) describes a direct method of drug delivery to the brain
through intraparenchymal microcatheters. By establishing a pressure gradient at the tip of …

[HTML][HTML] Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance

RA Marr, DM Hafez - Frontiers in aging neuroscience, 2014 - frontiersin.org
Accumulation of the amyloid-beta (Aβ) peptide is a central factor in Alzheimer's disease (AD)
pathogenesis as supported by continuing evidence. This review concisely summarizes this …

Role of HIV in amyloid metabolism

M Ortega, BM Ances - Journal of Neuroimmune Pharmacology, 2014 - Springer
HIV infection has changed from an acute devastating disease to a more chronic illness due
to combination anti-retroviral treatment (cART). In the cART era, the life expectancy of HIV …

Somatostatin receptor-4 agonists as candidates for treatment of Alzheimer's disease

KE Sandoval, KA Witt, AM Crider… - Drug design and …, 2014 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive
loss in memory and cognitive abilities. One of the key pathologic features of AD is the …

[HTML][HTML] Identification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches

KD Philibert, RA Marr, EM Norstrom… - Frontiers in Aging …, 2014 - frontiersin.org
Currently, there are very limited pharmaceutical interventions for Alzheimer's disease (AD) to
alleviate the amyloid burden implicated in the pathophysiology of the disease. Alzheimer's …