Highlights•ACh boosts attention by enhancing sensory stimuli and decreasing cortico-
cortical communication.•Increased ACh signaling can lead to symptoms of depression in …

The endocannabinoid system is widespread throughout the central nervous system and its
type 1 receptor (CB1) plays a crucial role in preventing the neurotoxicity caused by …

Accessible summary This randomized‐controlled trial investigated the effect of group
psychoeducation therapy on family burden in caregivers of Iranian patients with …

Objective Clinical and neurobiological data suggest that psychiatric disorders, as
traditionally defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM), are …

Schizophrenia is a chronic and often debilitating illness which affects about 1% of the world
population. Some reagents have been used to simulate schizophrenic disorders in …

The prefrontal cortex (PFC) is involved in higher brain functions altered in schizophrenia.
Classical antipsychotic drugs modulate information processing in cortico-limbic circuits via …

Schizophrenia has been considered a devastating clinical syndrome rather than a single
disease. Nevertheless, the mechanisms behind the onset of schizophrenia have been only …

Rationale Almost all antipsychotic drugs (APDs), irrespective of whether they belong to the
first-generation (eg haloperidol) or second-generation (eg clozapine), are dopamine D 2 …

The etiology of schizophrenia (SZ) is complex and largely unknown. Neuroimaging and
postmortem studies have suggested white matter disturbances in SZ. In the present study …

Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to
modulate, dopaminergic and other neurotransmitter systems involved in the …