Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease

DA Bennett, L Yu, PL De Jager - Biochemical pharmacology, 2014 - Elsevier
Cognitive decline, Alzheimer's disease (AD) and other causes are major public health
problems worldwide. With changing demographics, the number of persons with dementia …

[HTML][HTML] The dynamic relationship between cognitive function and positive well-being in older people: a prospective study using the English Longitudinal Study of …

M Allerhand, CR Gale, IJ Deary - Psychology and aging, 2014 - psycnet.apa.org
There is evidence that having a stronger sense of positive well-being may be a potential
resource for healthier aging as represented by slower physical decline, reduced risk of frailty …

Intervention-induced enhancement in intrinsic brain activity in healthy older adults

S Yin, X Zhu, R Li, Y Niu, B Wang, Z Zheng, X Huang… - Scientific reports, 2014 - nature.com
This study examined the effects of a multimodal intervention on spontaneous brain activity in
healthy older adults. Seventeen older adults received a six-week intervention that consisted …

[PDF][PDF] The timecourse of global cognitive gains from supervised computer-assisted cognitive training: a randomised, active-controlled trial in elderly with multiple …

A Lampit, H Hallock, R Moss, S Kwok… - J Prev Alzheimers …, 2014 - researchgate.net
BACKGROUND: Home-based computerised cognitive training (CCT) is ineffective at
enhancing global cognition, a key marker of cognitive ageing. OBJECTIVES: To test the …

Optimizing cognitive development over the life course and preventing cognitive decline: Introducing the Cognitive Health Environment Life Course Model (CHELM)

KJ Anstey - International Journal of Behavioral Development, 2014 - journals.sagepub.com
Optimal cognitive development is defined in this article as the highest level of cognitive
function reached in each cognitive domain given a person's biological and genetic …

Brain volumes in late life: gender, hormone treatment, and estrogen receptor variants

J Ryan, S Artero, I Carrière, J Scali, JJ Maller… - Neurobiology of …, 2014 - Elsevier
Structural imaging studies suggest gender differences in brain volumes; however, whether
hormone treatment (HT) can protect against age-related structural changes remains …

Is health affected by dementia worries and concerns about cognitive functioning?

SJ Cutler, LG Hodgson - Revista de Asistenta Sociala, 2014 - ceeol.com
The purpose of this research is to determine whether health is affected by concerns about
cognitive functioning and worries about developing dementia. Methods: The analysis is …

Social, behavioral, and contextual influences on cognitive function and decline over the life course

AK Leist, JP Mackenbach - Health and cognition in old age: From …, 2014 - Springer
Maintaining cognitive function is a prerequisite for living autonomously in older age and it is
highly desirable to postpone cognitive decline for as long as possible. In order to understand …

[PDF][PDF] Uma revisão para identificar variáveis ambientais que influenciam o envelhecimento humano para estudos de mineração de dados

CE Ribeiro, LE Zárate - … de Informática em Saúde. Santos, SP …, 2014 - researchgate.net
O envelhecimento humano é influenciado por fatores genéticos e ambientais. O estudo das
variáveis ambientais visa permitir a compreensão de como os hábitos do individuo …

[PDF][PDF] Implementação de um Programa de Treino Processual da atenção num Grupo de Idosos

RFL Alves - 2014 - core.ac.uk
Os défices relacionados com o envelhecimento da função cognitiva e sensorial podem
resultar na diminuição dos processos atencionais integrados na função cognitiva. O …