Pharmacogenetic research has the potential to explain the variation in treatment efficacy
within patient populations. Understanding the interaction between genetic variation and …

Sleep is a vital segment of life, however, the mechanisms of diet promoting sleep are
unclear and are the focus of research. Insomnia is a general sleep disorder and functional …

Methadone is the major opioid substitution therapy for opioid dependence. Dosage is highly
variable and is often controlled by the patient and prescriber according to local and national …

Methadone is a synthetic opioid that binds to the κ-opioid receptor with a low affinity. This
study tested the hypotheses that the genetic polymorphisms in the κ-opioid receptor 1 …

Methadone, a synthetic opioid, is mainly used as an analgesic and a maintenance
antiaddictive and reductive preparation in the treatment of opioid dependence. A better …

Temperature is an important factor affecting toxicity, determining chemical toxicokinetics and
toxicodynamics in poikilothermic organisms. Because metabolic rates also are affected by …

Abstract The Side Effects of Drugs Annuals forms a series of volumes in which the adverse
effects of drugs and adverse reactions to them are surveyed. The series supplements the …