Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes.
lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through …

Large‐scale characterization of post‐translational modifications (PTM s), such as
phosphorylation, acetylation and ubiquitination, has highlighted their importance in the …

Abstract Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …

How stage-specific enhancer dynamics modulate gene expression patterns essential for
organ development, homeostasis and disease is not well understood. Here, we addressed …

Cancer is a disease arising from both genetic and epigenetic modifications of DNA that
contribute to changes in gene expression in the cell. Genetic modifications include loss or …

It is widely accepted that epigenetic alterations are associated with different stages of tumour
formation and progression in many cancers. Therefore, epigenetic abnormalities in cancers …

The embryonic vertebrate heart tube develops an atrioventricular canal that divides the atrial
and ventricular chambers, forms atrioventricular conduction tissue and organizes valve …

The intestinal epithelium performs vital roles in organ function by absorbing nutrients and
providing a protective barrier. The zinc-finger containing transcription factors GATA4 and …

Numerous changes in epigenetic mechanisms have been described in various types of
tumors. In search for new biomarkers, we investigated the expression of Polycomb-group …

Protein arginine methyltransferase 5 (PRMT5), a protein arginine methyltransferase that
catalyzes the symmetrical dimethylation of arginine residues within target proteins, has been …