Gastric cancer remains highly prevalent and accounts for a notable proportion of global
cancer mortality. This cancer is also associated with poor survival rates. Understanding the …

The comparison of DNA methylation patterns across cancer types (pan-cancer methylome
analyses) has revealed distinct subgroups of tumors that share similar methylation patterns …

We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and
endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates …

Since its discovery 50 years ago, Epstein-Barr virus (EBV) has been linked to the
development of cancers originating from both lymphoid and epithelial cells. Approximately …

Patients with gastric and esophageal (GE) adenocarcinoma tumors in which the oncogene
ERBB2 has been amplified are routinely treated with a combination of cytotoxic …

Gastric cancer remains a major cancer problem world-wide and future incidence will likely
increase due to rapidly aging population demographics. Population-based screening is …

Dendrograms are graphical representations of binary tree structures resulting from
agglomerative hierarchical clustering. In Life Science, a cluster heat map is a widely …

Abstract Hereditary Diffuse Gastric Cancer is an autosomal dominant inherited gastric
cancer syndrome caused by germline alterations in CDH1 (E-cadherin) and CTNNA1 (alpha …

Gastric cancer is a leading cause of cancer deaths in the world. The treatment of gastric
cancer is challenging because of its highly heterogeneous etiology and clinical …

Currently, two histological classification systems are available to characterize gastric
adenocarcinomas, which represents the majority of gastric tumours. The Lauren …