Molecular tools for studying HIV transmission in sexual networks

MK Grabowski, AD Redd - Current Opinion in HIV and AIDS, 2014 - journals.lww.com
Phylogenetics is an important tool for HIV research, and offers opportunities to understand
critical aspects of the HIV epidemic. Like all epidemiological research, the methods used …

Phylogenetic studies of transmission dynamics in generalized HIV epidemics: an essential tool where the burden is greatest?

AM Dennis, JT Herbeck, AL Brown… - JAIDS Journal of …, 2014 - journals.lww.com
Efficient and effective HIV prevention measures for generalized epidemics in sub-Saharan
Africa have not yet been validated at the population level. Design and impact evaluation of …

The global transmission network of HIV-1

JO Wertheim, AJ Leigh Brown, NL Hepler… - The Journal of …, 2014 - academic.oup.com
Human immunodeficiency virus type 1 (HIV-1) is pandemic, but its contemporary global
transmission network has not been characterized. A better understanding of the properties …

Using HIV networks to inform real time prevention interventions

SJ Little, SL Kosakovsky Pond, CM Anderson… - PloS one, 2014 - journals.plos.org
Objective To reconstruct the local HIV-1 transmission network from 1996 to 2011 and use
network data to evaluate and guide efforts to interrupt transmission. Design HIV-1 pol …

The role of viral introductions in sustaining community-based HIV epidemics in rural Uganda: evidence from spatial clustering, phylogenetics, and egocentric …

MK Grabowski, J Lessler, AD Redd, J Kagaayi… - PLoS …, 2014 - journals.plos.org
Background It is often assumed that local sexual networks play a dominant role in HIV
spread in sub-Saharan Africa. The aim of this study was to determine the extent to which …

Phylogenetic analyses reveal HIV-1 infections between men misclassified as heterosexual transmissions

S Hué, AE Brown, M Ragonnet-Cronin, SJ Lycett… - Aids, 2014 - journals.lww.com
Objective: HIV-1 subtype B infections are associated with MSM in the UK. Yet, around 13%
of subtype B infections are found in those reporting heterosexual contact as transmission …

Impact of sampling density on the extent of HIV clustering

V Novitsky, S Moyo, Q Lei, V DeGruttola… - AIDS research and …, 2014 - liebertpub.com
Identifying and monitoring HIV clusters could be useful in tracking the leading edge of HIV
transmission in epidemics. Currently, greater specificity in the definition of HIV clusters is …

An HIV epidemic model based on viral load dynamics: value in assessing empirical trends in HIV virulence and community viral load

JT Herbeck, JE Mittler, GS Gottlieb… - PLoS computational …, 2014 - journals.plos.org
Trends in HIV virulence have been monitored since the start of the AIDS pandemic, as
studying HIV virulence informs our understanding of HIV epidemiology and pathogenesis …

Phylogenetic analysis provides evidence of interactions between Italian heterosexual and South American homosexual males as the main source of national HIV‐1 …

A Lai, G Bozzi, M Franzetti, F Binda… - Journal of medical …, 2014 - Wiley Online Library
The HIV‐1 clade C is prevalent worldwide and spread from Africa to South East Asia and
South America early in the course of the epidemic. As a consequence of migration waves …

Different trends of transmitted HIV-1 drug resistance in Madrid, Spain, among risk groups in the last decade

G Yebra, R Delgado, F Pulido, R Rubio, JC Galán… - Archives of …, 2014 - Springer
The presence of transmitted HIV drug resistance (TDR) threatens the efficacy of antiretroviral
treatment. We aimed to assess the changes in TDR prevalence over the last decade in …