Protein post-translational modifications and regulation of pluripotency in human stem cells
Post-translational modifications (PTMs) are known to be essential mechanisms used by
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …
The functional diversity of protein lysine methylation
S Lanouette, V Mongeon, D Figeys… - Molecular systems …, 2014 - embopress.org
Large‐scale characterization of post‐translational modifications (PTM s), such as
phosphorylation, acetylation and ubiquitination, has highlighted their importance in the …
phosphorylation, acetylation and ubiquitination, has highlighted their importance in the …
Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells
The histone demethylase LSD1 (KDM1A) demethylates mono-and di-methylated (Me2)
lysine (K) 4 on histone H3. High LSD1 expression blocks differentiation and confers a poor …
lysine (K) 4 on histone H3. High LSD1 expression blocks differentiation and confers a poor …
Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth
S Sankar, ER Theisen, J Bearss, T Mulvihill… - Clinical cancer …, 2014 - AACR
Purpose: Ewing sarcoma is a pediatric bone tumor that absolutely relies on the
transcriptional activity of the EWS/ETS family of fusion oncoproteins. While the most common …
transcriptional activity of the EWS/ETS family of fusion oncoproteins. While the most common …
Epigenetic regulation in cancer progression
Cancer is a disease arising from both genetic and epigenetic modifications of DNA that
contribute to changes in gene expression in the cell. Genetic modifications include loss or …
contribute to changes in gene expression in the cell. Genetic modifications include loss or …
The roles of Jumonji-type oxygenases in human disease
C Johansson, A Tumber, KH Che, P Cain, R Nowak… - …, 2014 - Taylor & Francis
The iron-and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically
conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on …
conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on …
[HTML][HTML] Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity
Summary Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional
corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator …
corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator …
Diverse epigenetic mechanisms of human disease
E Brookes, Y Shi - Annual review of genetics, 2014 - annualreviews.org
Epigenetic control of gene expression programs is essential for normal organismal
development and cellular function. Abrogation of epigenetic regulation is seen in many …
development and cellular function. Abrogation of epigenetic regulation is seen in many …
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair
H Khoury-Haddad, N Guttmann-Raviv… - Proceedings of the …, 2014 - National Acad Sciences
Members of the lysine (K)-specific demethylase 4 (KDM4) A–D family of histone
demethylases are dysregulated in several types of cancer. Here, we reveal a previously …
demethylases are dysregulated in several types of cancer. Here, we reveal a previously …
TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres
A Porro, S Feuerhahn, J Lingner - Cell reports, 2014 - cell.com
Telomeres protect chromosome ends from being recognized as sites of DNA damage. Upon
telomere shortening or telomere uncapping induced by loss of telomeric repeat-binding …
telomere shortening or telomere uncapping induced by loss of telomeric repeat-binding …