Alzheimer's disease (AD) is a devastative neurodegenerative disorder with complex
etiology. Apoptosis, a biological process that plays an essential role in normal physiology to …

AD, a devastating neurodegenerative disorder, is the most common cause of dementia in
the elderly. Patients with AD are characterized by three hallmarks of neuropathology …

Down Syndrome (DS) patients develop characteristic Alzheimer's Disease (AD)
neuropathology after their middle age. Prominent neuronal loss has been observed in the …

Mitophagy, a cellular process that selectively targets dysfunctional mitochondria for
degradation, is currently a hot topic in research into the pathogenesis and treatment of many …

Mitochondrial dysfunction induced by myocardial ischemia is the primary cause of cardiac
cell death. Specific removal of damaged mitochondria through mitophagy may be beneficial …

Regulator of calcineurin 1 (RCAN1) has been implicated in pathogenesis of
neurodegeneration and various cancers. Recently, we showed that RCAN1 expression was …

Atherosclerosis, one of the main causes of cardiovascular diseases, is a complex process
that involves manifold factors. Besides the vascular lipids accumulation, inflammatory factors …

Glycosylation is one of the major post-translational modifications, required for proper folding
and functions of glycoproteins. N-glycosylation in ER is mediated by …

Prion diseases are fatal and incurable neurodegenerative diseases that share many
pathological similarities to other neurodegenerative diseases such as Alzheimer's or …

Stroke is a leading cause of morbidity and mortality in the United States and worldwide.
However, few effective therapeutic interventions exist to treat this devastating disease. A …