Transcriptional landscape of the prenatal human brain
The anatomical and functional architecture of the human brain is mainly determined by
prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the …
prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the …
mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert
JT Rodgers, KY King, JO Brett, MJ Cromie… - Nature, 2014 - nature.com
A unique property of many adult stem cells is their ability to exist in a non-cycling, quiescent
state. Although quiescence serves an essential role in preserving stem cell function until the …
state. Although quiescence serves an essential role in preserving stem cell function until the …
[HTML][HTML] Aerobic glycolysis in the human brain is associated with development and neotenous gene expression
Aerobic glycolysis (AG; ie, nonoxidative metabolism of glucose despite the presence of
abundant oxygen) accounts for 10%–12% of glucose used by the adult human brain. AG …
abundant oxygen) accounts for 10%–12% of glucose used by the adult human brain. AG …
Sex differences in the human peripheral blood transcriptome
R Jansen, S Batista, AI Brooks, JA Tischfield… - BMC genomics, 2014 - Springer
Background Genomes of men and women differ in only a limited number of genes located
on the sex chromosomes, whereas the transcriptome is far more sex-specific. Identification …
on the sex chromosomes, whereas the transcriptome is far more sex-specific. Identification …
Cross-study validation for the assessment of prediction algorithms
Motivation: Numerous competing algorithms for prediction in high-dimensional settings have
been developed in the statistical and machine-learning literature. Learning algorithms and …
been developed in the statistical and machine-learning literature. Learning algorithms and …
Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin
M Bsibsi, LAN Peferoen, IR Holtman, PJ Nacken… - Acta …, 2014 - Springer
Activated microglia and macrophages play a key role in driving demyelination during
multiple sclerosis (MS), but the factors responsible for their activation remain poorly …
multiple sclerosis (MS), but the factors responsible for their activation remain poorly …
A common gene expression signature in Huntington's disease patient brain regions
Background Gene expression data provide invaluable insights into disease mechanisms. In
Huntington's disease (HD), a neurodegenerative disease caused by a tri-nucleotide repeat …
Huntington's disease (HD), a neurodegenerative disease caused by a tri-nucleotide repeat …
Differential induction of TLR3-dependent innate immune signaling by closely related parasite species
The closely related protozoan parasites Toxoplasma gondii and Neospora caninum display
similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and …
similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and …
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies
E Perez-Palma, BI Bustos, CF Villaman, MA Alarcon… - PloS one, 2014 - journals.plos.org
Genome-wide association studies (GWAS) have successfully identified several risk loci for
Alzheimer's disease (AD). Nonetheless, these loci do not explain the entire susceptibility of …
Alzheimer's disease (AD). Nonetheless, these loci do not explain the entire susceptibility of …
Improving reliability and absolute quantification of human brain microarray data by filtering and scaling probes using RNA-Seq
Background High-throughput sequencing is gradually replacing microarrays as the
preferred method for studying mRNA expression levels, providing nucleotide resolution and …
preferred method for studying mRNA expression levels, providing nucleotide resolution and …