Purpose Radiation therapy (RT) can both suppress and stimulate the immune system. We
sought to investigate the mechanisms underlying radiation-induced lymphopenia and its …

In the context of transfusion medicine, alloimmunization most often refers to the development
of antibodies to non-ABO red blood cell (RBC) antigens following pregnancy, transfusion, or …

The adaptive immune system requires a diverse T‐cell repertoire to be able to respond to a
wide variety of pathogens. Worryingly, the repertoire diversity declines dramatically in old …

The effect of aging on natural killer cell homeostasis is not well studied in humans or in
animal models. We compared natural killer (NK) cells from young and aged mice to …

The ability to reconstitute a normal immune system with antiretroviral therapy in the setting of
HIV infection remains uncertain. This study aimed to characterize quantitative and qualitative …

A main objective of current medical research is to improve the life quality of elderly people
as priority of the continuous increase of ageing population. This phenomenon implies …

Lymphopenia-induced proliferation (LIP), a mechanism to maintain a constant number of T
cells in circulation, occurs in both normal aging and autoimmune disease. The incidence of …

Epstein–Barr virus (EBV) is present in 95% of the world's adult population. The immune
response participates in immune vigilance and persistent infection control, and this condition …

By 2050, there will be more than 1.6 billion adults 65 years and older worldwide, making
age-related diseases and conditions a growing public health concern [1]. One cannot …

Environmental studies performed in Panasqueira mine area (central Portugal) identified
high concentrations of several metal (loid) s in environmental media, and individuals …