Organ and tissue loss through disease and injury motivate the development of therapies that
can regenerate tissues and decrease reliance on transplantations. Regenerative medicine …

The spectrum of ischaemic cardiomyopathy, encompassing acute myocardial infarction to
congestive heart failure is a significant clinical issue in the modern era. This group of …

Cardiac tissue engineering is a promising approach to provide large-scale tissues for
transplantation to regenerate the heart after ischemic injury, however, integration with the …

Nitric oxide (NO) is an important signaling molecule in cardiovascular system, and the
sustained release of NO by endothelial cells plays a vital role in maintaining patency and …

Tissue engineering is well suited for the treatment of cardiac disease due to the limited
regenerative capacity of native cardiac tissue and the loss of function associated with …

Treating a myocardial infarction (MI), the most frequent cause of death worldwide, remains
one of the most exciting medical challenges in the 21st century. Cardiac tissue engineering …

Tissue engineering opens up a new area to restore the function of damaged tissue or
replace a defective organ. Common strategies in tissue engineering to repair and form new …

All tissue-engineered substitutes (with the exception of cornea and cartilage) require a
vascular network to provide the nutrient and oxygen supply needed for their survival in vivo …

The cardiac ECM has a unique 3D structure responsible for tissue morphogenesis and
strong contractions. It is divided into three fiber groups with specific roles and distinct …

Functional vascularization is a prerequisite for cardiac tissue engineering of constructs with
physiological thicknesses. We previously reported the successful preservation of main …