Accumulating evidence indicates that aging is associated with a chronic low-level
inflammation, termed sterile-inflammation. Sterile-inflammation is a form of pathogen-free …

Recent research suggests a complex role for microglia not only in Parkinson's disease but in
other disorders involving alpha-synuclein aggregation, such as multiple system atrophy. In …

Synucleinopathies, such as Parkinson's disease and diffuse Lewy body disease, are
progressive neurodegenerative disorders characterized by selective neuronal death …

The proteins alpha-synuclein (αSyn) and leucine rich repeat kinase 2 (LRRK2) are both key
players in the pathogenesis of the neurodegenerative disorder Parkinson's disease (PD) …

Abstract Alpha-synuclein (α-synuclein) is considered a key player in Parkinson's disease
(PD), but the exact relationship between α-synuclein aggregation and dopaminergic …

The discovery of alpha-synuclein's prion-like behaviors in mammals, as well as a non-
Mendelian type of inheritance, has led to a new concept in biology, the “prion hypothesis” of …

Numerous studies have revealed the pleiotropic functions of tumor necrosis factor alpha
(TNF-α), and have linked it with several neurodegenerative disorders. This review describes …

The flow of information that governs the working in all living forms culminates with proteins
which are responsible for a diverse array of cellular processes. However the mere synthesis …