The preproglucagon gene (Gcg) is expressed by specific enteroendocrine cells (L-cells) of
the intestinal mucosa, pancreatic islet α-cells, and a discrete set of neurons within the …

The prevalence of type 2 diabetes is increasing at an astounding rate. Many of the agents
used to treat type 2 diabetes have undesirable adverse effects of hypoglycemia and weight …

Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and
the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen …

Bile acids are well-recognized stimuli of glucagon-like peptide-1 (GLP-1) secretion. This
action has been attributed to activation of the G protein–coupled bile acid receptor GPBAR1 …

Glucagon is secreted from islet α cells and controls blood levels of glucose in the fasting
state. Impaired glucagon secretion predisposes some patients with type 1 diabetes mellitus …

Diabetes Mellitus (DM) is the fastest growing metabolic disorder affecting about 387 million
people across the globe and is estimated to affect 592 million people by year 2030. The …

The rate of gastric emptying is a critical determinant of postprandial glycaemia and,
accordingly, is fundamental to maintaining blood glucose homeostasis. Disordered gastric …

OBJECTIVE To assess the safety and efficacy of dual sodium–glucose cotransporter (SGLT)
1 and SGLT2 inhibition with sotagliflozin as adjunct therapy to insulin in type 1 diabetes …

The endoplasmic reticulum (ER) is involved in the development of insulin resistance and
progression to type 2 diabetes mellitus (T2DM). Disruption of ER homeostasis leads to ER …

The inactive full-length form of GLP-1 (1-37) stimulates conversion of both rat and human
intestinal epithelial cells into insulin-secreting cells. We investigated whether oral …