Large-scale genomic investigations have just begun to illuminate the molecular genetic
contributions to major psychiatric illnesses, ranging from small-effect-size common variants …

Recent large-scale genomic studies have revealed two broad classes of risk alleles for
schizophrenia: a polygenic component of risk mediated through multiple common risk …

Abstract The Tohoku Medical Megabank Organization reports the whole-genome
sequences of 1,070 healthy Japanese individuals and construction of a Japanese …

The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and
Bleuler began documenting their findings. However, large clinical research efforts in recent …

CME Harvard Review of Psychiatry offers CME for readers who complete questions about
featured articles. Questions can be accessed from the Harvard Review of Psychiatry website …

The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously
expressed in both the central nervous system and in the periphery. CHRNA7 is genetically …

Patients with the 15q11. 2 BP1–BP2 microdeletion can present with developmental and
language delay, neurobehavioral disturbances and psychiatric problems. Autism, seizures …

In the past decade, the view on genomic structural variation (SV) has been changed
completely. SVs, previously considered rare events, are now recognized as the largest …

Schizophrenia is a complex mental health disorder with positive, negative and cognitive
symptom domains. Approximately one third of patients are resistant to currently available …

Schizophrenia is associated with alterations in working memory that reflect dysfunction of
dorsolateral prefrontal cortex (DLPFC) circuitry. Working memory depends on the activity of …