Genetics studies of autism spectrum disorder (ASD) have identified several risk genes that
are key regulators of synaptic plasticity. Indeed, many of the risk genes that have been …

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

The structure and function of the human brain are highly stereotyped, implying a conserved
molecular program responsible for its development, cellular structure and function. We …

Increasing evidence points to a central role for immune dysregulation in autism spectrum
disorder (ASD). Several ASD risk genes encode components of the immune system and …

High-throughput transcriptomic profiling approaches have revealed that alternative splicing
(AS) of precursor mRNAs, a fundamental process by which cells expand their transcriptomic …

Autism spectrum disorder is typical of the majority of neuropsychiatric syndromes in that it is
defined by signs and symptoms, rather than by aetiology. Not surprisingly, the causes of this …

Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Synaptic dysfunction is a hallmark of many neurodegenerative and psychiatric brain
disorders, yet we know little about the mechanisms that underlie synaptic vulnerability …

Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple
genetic associations with such disorders, but better methods are needed to derive the …

The emerging roles of microglia are currently being investigated in the healthy and diseased
brain with a growing interest in their diverse functions. In recent years, it has been …