Disease models are essential for understanding cardiovascular disease pathogenesis and
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …

Mitochondrial fitness is central to heart health. In many cell types, mitochondria are dynamic,
interconnected filamentous networks. By comparison, mitochondria of healthy postmitotic …

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are widely used
in studying basic mechanisms of cardiac arrhythmias that are caused by ion …

The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after
cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling …

Adult cardiomyocytes exhibit complex Ca2+ homeostasis, enabling tight control of
contraction and relaxation. This intricate regulatory system develops gradually, with …

Background Human genetically inherited cardiac diseases have been studied mainly in
heterologous systems or animal models, independent of patients' genetic backgrounds …

Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) assert a
great future for the cardiovascular diseases, both to study them and to explore therapies …

Pompe disease is an autosomal recessive inherited metabolic disease caused by deficiency
of acid α-glucosidase (GAA). Glycogen accumulation is seen in the affected organ such as …

Background An in vitro electrophysiological assay system, which can assess compound
effects and thus show cardiotoxicity including arrhythmia risks of test drugs, is an essential …

In spite of their relative rarity, inheritable arrhythmias have come to the forefront as a group
of potentially fatal but preventable cause of sudden cardiac death in children and (young) …