Macrophage activation syndrome (MAS) is an acute episode of overwhelming inflammation
characterized by activation and expansion of T lymphocytes and hemophagocytic …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by extreme
immune activation, resulting in pathologic inflammation. The diagnosis includes a spectrum …

Objective Systemic juvenile idiopathic arthritis (JIA) is associated with high levels of
interleukin‐6 (IL‐6) in the serum and synovial fluid, and impairment of natural killer (NK) cell …

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Background Macrophage activation syndrome (MAS) is a severe and potentially lethal
complication of several inflammatory diseases but seems particularly linked to systemic …

Translational research approaches brought major changes to the understanding and
treatment options of autoinflammatory diseases. Patients with common complex …

Whether it is due to changing epidemiology or increased recognition, hyperferritinemic
sepsis is becoming increasingly diagnosed in critically ill children. An acute rise in ferritin is …

Familial hemophagocytic lymphohistiocytosis (FHL) is a rare, life-threatening, inherited
hyperinflammatory syndrome that may be clinically indistinguishable from secondary forms …

Translating pathogenic insights gained from monogenic defects that cause autoinflammatory
diseases into novel therapies has dramatically improved the lives of patients with these …

There are an estimated 6000–8000 rare Mendelian diseases that collectively affect 30
million individuals in the United States. The low incidence and prevalence of these diseases …