Over the last decade, there has been a significant increase in average paternal age when
the first child is conceived, either due to increased life expectancy, widespread use of …

Elderly adults constitute a rapidly growing part of the global population, thus resulting in an
increase in morbidity and mortality related to cardiovascular disease (CVD), which remains …

Increased fat mass and fat redistribution are commonly observed in aging populations
worldwide. Although decreased circulating levels of sex hormones, androgens and …

A number of health and lifestyle factors are thought to contribute to cognitive decline
associated with age but cannot be easily modified by the individual patient. We identified 12 …

Objectives To test the hypothesis that men and women with low bone mineral density (BMD)
and sarcopenia have a higher risk of fracture than those with only one or neither conditions …

Steroidogenesis begins with cholesterol transfer into mitochondria through the
transduceosome, a complex composed of cytosolic proteins that include steroidogenesis …

Dry eye (DE) is a multifactorial disorder of the ocular surface unit that results in eye
discomfort, visual disturbance and ocular surface damage. It is one of the most common …

A significant proportion of patients with type 2 diabetes mellitus have a low testosterone
level relative to reference ranges based on healthy young men. Only a small number of …

Aim The age-specific population profiles in men of circulating testosterone and its two
bioactive metabolites dihydrotestosterone (DHT) and estradiol (E2) across the adult lifespan …

Context: The prevalence of sexual dysfunction, low vitality, and poor physical function
increases with aging, as does the prevalence of low total and free testosterone (TT and FT) …