53BP1 promotes microhomology-mediated end-joining in G1-phase cells
Alternative non-homologous end joining (alt-NHEJ) was originally identified as a backup
repair mechanism in the absence of classical NHEJ (c-NHEJ) factors but recent studies have …
repair mechanism in the absence of classical NHEJ (c-NHEJ) factors but recent studies have …
BRCA 1 and Ct IP promote alternative non‐homologous end‐joining at uncapped telomeres
Loss of telomere protection occurs during physiological cell senescence and ageing, due to
attrition of telomeric repeats and insufficient retention of the telomere‐binding factor TRF 2 …
attrition of telomeric repeats and insufficient retention of the telomere‐binding factor TRF 2 …
Dose response and adaptive response of non-homologous end joining repair genes and proteins in resting human peripheral blood mononuclear cells exposed to γ …
S Shelke, B Das - Mutagenesis, 2015 - academic.oup.com
Ionising radiation induces single-strand breaks, double-strand breaks (DSB) and base
damages in human cell. DSBs are the most deleterious and if not repaired may lead to …
damages in human cell. DSBs are the most deleterious and if not repaired may lead to …
NKX3.1 Suppresses TMPRSS2–ERG Gene Rearrangement and Mediates Repair of Androgen Receptor–Induced DNA Damage
C Bowen, T Zheng, EP Gelmann - Cancer research, 2015 - AACR
TMPRSS2 gene rearrangements occur at DNA breaks formed during androgen receptor–
mediated transcription and activate expression of ETS transcription factors at the early …
mediated transcription and activate expression of ETS transcription factors at the early …
Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors
AG Goglia, R Delsite, AN Luz, D Shahbazian… - Molecular cancer …, 2015 - AACR
Most cancer therapies involve a component of treatment that inflicts DNA damage in tumor
cells, such as double-strand breaks (DSBs), which are considered the most serious threat to …
cells, such as double-strand breaks (DSBs), which are considered the most serious threat to …
[HTML][HTML] AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts
Emerging evidence suggests that activation of adenosine monophosphate-activated protein
kinase (AMPK), an energy gauge and redox sensor, controls the cell cycle and protects …
kinase (AMPK), an energy gauge and redox sensor, controls the cell cycle and protects …
Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks
K Muraki, L Han, D Miller, JP Murnane - Nucleic acids research, 2015 - academic.oup.com
The caps on the ends of chromosomes, called telomeres, keep the ends of chromosomes
from appearing as DNA double-strand breaks (DSBs) and prevent chromosome fusion …
from appearing as DNA double-strand breaks (DSBs) and prevent chromosome fusion …
Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein
Y Yuan, S Britton, C Delteil, J Coates… - Nucleic Acids …, 2015 - academic.oup.com
In humans, DNA double-strand breaks (DSBs) are repaired by two mutually-exclusive
mechanisms, homologous recombination or end-joining. Among end-joining mechanisms …
mechanisms, homologous recombination or end-joining. Among end-joining mechanisms …
[PDF][PDF] The role of MAR elements in DNA recombination
K Kostyrko - 2015 - serval.unil.ch
The untargeted integration of foreign DNA into the mammalian cell genome, extensively
used in gene therapy and biotechnology, remains an incompletely understood process. It is …
used in gene therapy and biotechnology, remains an incompletely understood process. It is …