A prolonged QT interval is an important risk factor for ventricular arrhythmias and sudden
cardiac death. QT prolongation can be caused by drugs. There are multiple risk factors for …

Cardiovascular morbidity and mortality are important problems among patients with
schizophrenia. A wide spectrum of reasons, ranging from genes to the environment, are held …

Background Antipsychotics have been linked to prolongation of the QT interval. However,
little is known about the risk of ventricular arrhythmia (VA) and/or sudden cardiac death …

Clinicians already face “personalized” medicine every day while experiencing the great
variation in toxicities and drug efficacy among individual patients. Pharmacogenetics studies …

Aim: To provide insight into potential regulatory mechanisms of gene expression underlying
addiction, analgesia, psychotropic drug response and adverse drug events, genome-wide …

The 4D nucleome has the potential to render challenges in neuropsychiatric
pharmacogenomics more tractable. The epigenome roadmap consortium has demonstrated …

Pharmacogenetics has been driven by a candidate gene approach. The disadvantage of
this approach is that is limited by our current understanding of the mechanisms by which …

Antidepressants are widely administered to chronic pain patients, but there is large
interindividual variability in their efficacy and adverse effect rates that may be attributed to …

Schizophrenia and other psychoses are complex disorders with high rates of cognitive
impairment and a considerable degree of genetic and environmental influence on its …

Cardiovascular disease (CVD) is one of the leading causes of death in the general
population. An overwhelming body of evidence suggests that patients with serious mental …