Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective
D Albuquerque, E Stice, R Rodríguez-López… - Molecular genetics and …, 2015 - Springer
It is well-known that obesity is a complex multifactorial and heterogeneous condition with an
important genetic component. Recently, major advances in obesity research emerged …
important genetic component. Recently, major advances in obesity research emerged …
[HTML][HTML] Current applications of genetic risk scores to cardiovascular outcomes and subclinical phenotypes
Genetic risk scores are a useful tool for examining the cumulative predictive ability of genetic
variation on cardiovascular disease. Important considerations for creating genetic risk …
variation on cardiovascular disease. Important considerations for creating genetic risk …
Polygenic influence on educational attainment: New evidence from the National Longitudinal Study of Adolescent to Adult Health
Recent studies have begun to uncover the genetic architecture of educational attainment.
We build on this work using genome-wide data from siblings in the National Longitudinal …
We build on this work using genome-wide data from siblings in the National Longitudinal …
Lifetime socioeconomic status, historical context, and genetic inheritance in shaping body mass in middle and late adulthood
This study demonstrates that body mass in middle and late adulthood is a consequence of
the complex interplay among individuals' genes, lifetime socioeconomic experiences, and …
the complex interplay among individuals' genes, lifetime socioeconomic experiences, and …
[HTML][HTML] A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intake
There is little evidence about genetic risk score (GRS)–diet interactions in order to provide
personalized nutrition based on the genotype. The aim of the study was to assess the value …
personalized nutrition based on the genotype. The aim of the study was to assess the value …
The mathematical limits of genetic prediction for complex chronic disease
Background Attempts at predicting individual risk of disease based on common germline
genetic variation have largely been disappointing. The present paper formalises why …
genetic variation have largely been disappointing. The present paper formalises why …
Genetics of weight loss: A basis for personalized obesity management
JA Martínez, FI Milagro - Trends in Food Science & Technology, 2015 - Elsevier
Highlights•Single nucleotide polymorphisms (SNP) can influence individual responses to
diet.•Gene variants can be used for personalization and optimization of obesity treatment.•A …
diet.•Gene variants can be used for personalization and optimization of obesity treatment.•A …
[HTML][HTML] Big data challenges in bone research: genome-wide association studies and next-generation sequencing
Genome-wide association studies (GWAS) have been developed as a practical method to
identify genetic loci associated with disease by scanning multiple markers across the …
identify genetic loci associated with disease by scanning multiple markers across the …
Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies
T Wang, W Jia, C Hu - Frontiers of Medicine, 2015 - Springer
Obesity prevalence has increased in recent years. Lifestyle change fuels obesity, but genetic
factors cause more than 50% of average variations in obesity. The advent of genome-wide …
factors cause more than 50% of average variations in obesity. The advent of genome-wide …
Progressive influence of body mass index-associated genetic markers in rural Gambians
Background In populations of European ancestry, the genetic contribution to body mass
index (BMI) increases with age during childhood but then declines during adulthood …
index (BMI) increases with age during childhood but then declines during adulthood …