Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart
failure (HF) in older adults, particularly women, and is increasing in prevalence as the …

Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that
represents an increasing health problem, especially in the elderly population. Drug …

The aging process is perceived as resulting from a combination of intrinsic factors such as
changes in intracellular signaling and extrinsic factors, most notably environmental …

Aim It is now clear that insulin signaling has important roles in regulation of neuronal
functions in the brain. Dysregulation of brain insulin signaling has been linked to …

Background Oxidative stress is strongly associated with aging and age-related diseases and
plays a crucial role in endothelial dysfunction development. Aim To better understand the …

Despite recent advances, the role of ROS in mediating hypertrophic and apoptotic
responses in cardiac myocytes elicited by norepinephrine (NE) is rather poorly understood …

The sirtuins comprise a highly conserved family proteins present in virtually all species from
bacteria to mammals. Sirtuins are members of the highly conserved class III histone …

Testicular cord formation in male gonadogenesis involves assembly of several cell types,
the precise molecular mechanism is still not well known. With the high-throughput …

Isoproterenol (ISO) induced nuclear translocation of calpain‐2 which further increased
susceptibility of cardiomyocyte apoptosis in tail‐suspended rats. The underlying …

Oxidative stress has been shown to play a role in the etiology of several chronic diseases,
including cardiovascular disease, diabetes mellitus, and cancer. Free radicals and, most …