Dissection of the genetic basis of Aicardi–Goutières syndrome has highlighted a
fundamental link between nucleic acid metabolism, innate immune sensors and type I …

To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell,
co-opting mechanisms of cellular physiology while defeating restriction factors that are …

Dysfunction in Ataxia-telangiectasia mutated (ATM), a central component of the DNA repair
machinery, results in Ataxia Telangiectasia (AT), a cancer-prone disease with a variety of …

Objectives The HIV restriction factor, SAMHD1 (SAM domain and HD domain-containing
protein 1), is a triphosphohydrolase that degrades deoxyribonucleoside triphosphates …

Regulation of intracellular deoxynucleoside triphosphate (dNTP) pool is critical to genomic
stability and cancer development. Imbalanced dNTP pools can lead to enhanced …

Cytokines and IFNs downstream of innate immune pathways are critical for mounting an
appropriate immune response to microbial infection. However, the expression of these …

SAMHD1 is a nuclear deoxyribonucleoside triphosphate triphosphohydrolase that
contributes to the control of cellular deoxyribonucleoside triphosphate (dNTP) pool sizes …

Intrinsic restriction factors and viral nucleic acid sensors are important for the anti-viral
response. Here, we show how upstream sensing of retroviral reverse transcripts integrates …

Background Human SAMHD1 is a triphosphohydrolase that restricts the replication of
retroviruses, retroelements and DNA viruses in noncycling cells. While modes of action have …

Cyclins control the activation of cyclin-dependent kinases (CDK), which in turn, control the
cell cycle and cell division. Intracellular availability of deoxynucleotides (dNTP) plays a …