As we age, the immune system undergoes a process of senescence accompanied by the
increased production of proinflammatory cytokines, a chronic subclinical condition named as …

Background Ageing brings about the gradual deterioration of the immune system, also
known as immunosenescence. The role of non-coding circular RNA in immunosenescence …

Besides growing plants, eating a lot, and drinking beer, Tolkien's Hobbits enjoy maintaining
a quiet state. Regarding the latter, the name chosen for a recently discovered transcription …

Background Aging and latent infection with Cytomegalovirus (CMV) are thought to be major
factors driving the immune system towards immunosenescence, primarily characterized by …

A subset of older people is at increased risk of hospitalization and dependency. Emerging
evidence suggests that immunosenescence reflected by an inverted CD4: 8 ratio and …

Background Despite effective antiretroviral therapy (ART), HIV-infected patients exhibit
systemic inflammation, early onset of age-related diseases, and features of …

Tumor cells escape immune eradication through multiple mechanisms, including loss of
antigenicity and local suppression of effector lymphocytes. To counteract these obstacles …

Ageing has been associated with progressive molecular and structural changes causing
loss of function in several organs. There is a general hypothesis that very old individuals …

Cytomegalovirus (CMV) is well known for producing severe life-threatening infection in
immunocompromised hosts (HIV, organ transplant). CMV latently infects immune competent …

Some viruses are able to escape the immune responses generated against them and to
establish a latent state that is not visible to the immune system. Such viruses hide in CD4+ T …