[HTML][HTML] Bmi-1: At the crossroads of physiological and pathological biology
Bmi-1 is a member of the Polycomb repressor complex 1 that mediates gene silencing by
regulating chromatin structure and is indispensable for self-renewal of both normal and …
regulating chromatin structure and is indispensable for self-renewal of both normal and …
[HTML][HTML] DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression
MH Cho, JH Park, HJ Choi, MK Park, HY Won… - Nature …, 2015 - nature.com
DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its
functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates …
functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates …
[HTML][HTML] A novel aspect of tumorigenesis—BMI1 functions in regulating DNA damage response
BMI1 plays critical roles in maintaining the self-renewal of hematopoietic, neural, intestinal
stem cells, and cancer stem cells (CSCs) for a variety of cancer types. BMI1 promotes cell …
stem cells, and cancer stem cells (CSCs) for a variety of cancer types. BMI1 promotes cell …
[HTML][HTML] MicroRNA-31 is a transcriptional target of histone deacetylase inhibitors and a regulator of cellular senescence
JH Cho, M Dimri, GP Dimri - Journal of Biological Chemistry, 2015 - ASBMB
MicroRNAs (miRNAs) have emerged as important regulators of tumorigenesis. Several
miRNAs, which can function either as oncomiRs or tumor suppressive miRs are deregulated …
miRNAs, which can function either as oncomiRs or tumor suppressive miRs are deregulated …
[HTML][HTML] The BMI1 polycomb protein represses cyclin G2-induced autophagy to support proliferation in chronic myeloid leukemia cells
L Mourgues, V Imbert, M Nebout, P Colosetti, Z Neffati… - Leukemia, 2015 - nature.com
The BMI1 polycomb protein regulates self-renewal, proliferation and survival of cancer-
initiating cells essentially through epigenetic repression of the CDKN2A tumor suppressor …
initiating cells essentially through epigenetic repression of the CDKN2A tumor suppressor …
Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis
Obscurins, encoded by the single OBSCN gene, are giant cytoskeletal proteins with
structural and regulatory roles. The OBSCN gene is highly mutated in different types of …
structural and regulatory roles. The OBSCN gene is highly mutated in different types of …
[HTML][HTML] HSPA12B: a novel facilitator of lung tumor growth
H Ma, T Lu, X Zhang, C Li, J Xiong, L Huang, P Liu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Lung tumor progression is regulated by proangiogenic factors. Heat shock protein A12B
(HSPA12B) is a recently identified regulator of expression of proangiogenic factors …
(HSPA12B) is a recently identified regulator of expression of proangiogenic factors …
脑转移瘤发生机制的研究进展
鄢少聪， 应学明 - 现代肿瘤医学, 2015 - cqvip.com
脑转移瘤发生机制的研究进展-[维普官方网站]-www.cqvip.com-维普网 我的维普 购物车 充值
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[HTML][HTML] Effect of BMI1 Knockdown on Cell Proliferation, Apoptosis, Invasiveness, and Migration of U251 Glioma Cells
D Kim, Y Jun, D Kim, JJ Kim - Korean Journal of Physical Anthropology, 2015 - e-aba.org
BMI1 belongs to the polycomb-repressive complex 1 (PRC1) family of genes that are
conserved chromatin silencers. These are essential for maintaining both the normal and …
conserved chromatin silencers. These are essential for maintaining both the normal and …